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    [26] They discovered that cortisone could be microbiologically prednisolone oxidized to prednisone by the bacterium Corynebacterium simplex . Prednisone is a synthetic prednisolone pregnane corticosteroid and derivative of cortisone and is also known as ?1-cortisone or 1,2-dehydrocortisone or as 17?,21-dihydroxypregna-1,4-diene-3,11,20-trione . [23][24][25] The first commercially feasible synthesis of prednisone was carried prednisolone taper prednisolone loading dose prednisolone rinse deltacortril ent 5mg prednisolone out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation, by Arthur Nobile and coworkers . [21][22] The first isolation prednisolone and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .
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