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Plasma levels of eszopiclone at eszopiclone half life lunesta groggy generic lunesta problems lunesta dementia lunesta vs. xanax to this dose are estimated to be 150 (females) and 70 (males) times those in humans receiving the MRHD .
The mechanism for the increase in mammary lunesta vs ambien xr lunesta side effects prostate lunesta generic price lunesta label lunesta adenocarcinomas is unknown .
The eszopiclone increase in thyroid tumors is thought to be due to increased levels of TSH secondary to increased metabolism of circulating thyroid hormones, a mechanism that is not considered to be relevant to humans .
In a carcinogenicity study in B6C3F1 mice in which racemic zopiclone was given in the diet, an increase in pulmonary carcinomas and carcinomas plus adenomas in females eszopiclone and an increase in 21476 FDA approved labeling text 1 . 08 skin fibromas and sarcomas eszopiclone in males were seen at the highest dose of 100 mg/kg/day .
Plasma levels of eszopiclone at this dose are estimated to be 8 eszopiclone (females) and 20 (males) times those in humans receiving the MRHD .
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