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Precautions

Co-administration of anastrozole and tamoxifen resulted in a reduction of arimidex anastrozole plasma levels by 27% compared with those achieved with anastrozole alone .
Estrogen-containing therapies should not be used with ARIMIDEX as arimidex they may diminish its pharmacologic action .
Drug/Laboratory Test Interactions No clinically significant changes in the results of clinical arimidex laboratory tests have been observed .
A conventional carcinogenesis study in rats at anastrozole hypercalcemia arimidex 10 years anastrozole risks anastrozole astrazeneca anastrozole doses of 1 . 0 to 25 mg/kg/day (about 10 to 243 times arimidex the daily maximum recommended human dose on a mg/m2 basis) administered by oral gavage for up to 2 years revealed an increase in the incidence of hepatocellular adenoma and carcinoma and uterine stromal polyps in females and thyroid adenoma in males at the high dose .
A dose arimidex effects on liver anastrozole medication arimidex for gyno on cycle anastrozole dental side related increase was observed in the incidence of ovarian and uterine hyperplasia in females .
At 25 mg/kg/day, plasma AUC0-24 hr levels in rats arimidex were 110 to 125 times higher than the level exhibited in postmenopausal volunteers at the recommended dose .
A separate carcinogenicity study in mice at oral doses of 5 to 50 mg/kg/day (about 24 to 243 times the daily maximum recommended human dose on a mg/m2 basis) for up to 2 years produced an increase in the incidence of benign arimidex testosterone arimidex and tamoxifen arimidex permanent damage zentiva arimidex anastrozole ovarian stromal, epithelial and granulosa cell tumors at all dose levels .
A dose related increase in the incidence of anastrozole endometrial cancer side effects from stopping arimidex arimidex liquid dosage arimidex ovarian hyperplasia was also observed in female mice .

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