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The terminal half-life of losartan losartan spc hyzaar tratamiento hyzaar yan etkisi valsartan contraindicaciones hyzaar webmd losartan is about 2 hours and of the metabolite is about 6-9 hours .
The pharmacokinetics of losartan and its active metabolite are linear with oral cozaar losartan doses up to 200 mg and do not change over time .
Neither losartan nor its metabolite accumulate in plasma upon repeated once-daily Following oral administration, losartan is well absorbed (based on absorption of radiolabeled losartan) and undergoes substantial first-pass metabolism; the valsartan krka biverkningar losartan stada 50 mg losartan kalium 100 mg hyzaar uses losartan 100 mg systemic bioavailability of losartan is approximately 33% .
About 14% of an orally-administered dose of losartan is converted to hyzaar mecanismo de accion hyzaar vs fortzaar valsartan effets secondaires cozaar 50 mg msd cozaar the active metabolite .
Mean peak concentrations of losartan and its active metabolite are cozaar reached in 1 hour and in 3-4 hours, respectively .
While maximum plasma concentrations of losartan effects losartan 50 mg efeito colateral hyzaar high cozaar componentes hyzaar fort fiyat losartan and its active metabolite are approximately equal, the AUC of the metabolite is about 4 times as great as that of losartan .
A meal slows cozaar absorption of losartan and decreases its Cmax but has only minor effects on losartan AUC or on the AUC of the metabolite (about 10% decreased) .
The pharmacokinetics of losartan and cozaar its active metabolite were also determined after IV doses of each component separately in healthy volunteers .
The volume of distribution of losartan and the active metabolite is about valsartan generic losartan epocrates valsartan filmtabletten hyzaar dose losartan green pill 34 liters and 12 liters, respectively .

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