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Full Description of COUMADIN

Table 1 displays coumadin three ranges of expected maintenance COUMADIN doses observed in subgroups of patients having different combinations of CYP2C9 and VKORC1 gene variants [see CLINICAL PHARMACOLOGY] .
If coumadin the patient’s CYP2C9 and/or VKORC1 genotype are known, consider these ranges in choosing the initial dose .
Patients with CYP2C9 *1/*3, *2/*2, *2/*3, and *3/*3 may require more coumadin prolonged time ( > 2 to 4 weeks) to achieve maximum INR effect for a given dosage regimen than patients without these CYP variants .
Table 1: Three Ranges of Expected Maintenance COUMADIN Daily Doses Based on CYP2C9 and VKORC1 Genotypes COUMADIN coumadin bleeding precautions coumadin dosages coumadin meds coumadin diet coumadin tablets dosage has a narrow therapeutic range (index), and its action may be affected by factors such as other drugs and dietary vitamin K .
Therefore, anticoagulation coumadin inr test what is coumadin therapy therapeutic inr on coumadin coumadin rash what does must be carefully monitored during COUMADIN therapy .
Determine the INR daily after the administration of the initial dose until INR what is coumadin used to treat coumadin levels too high normal inr on coumadin coumadin warfarin results stabilize in the therapeutic range .
After stabilization, maintain dosing within the therapeutic range by coumadin overdose side effects coumadin vs warfarin side effects coumadin management coumadin colors performing periodic INRs .
The frequency of performing coumadin INR should be based on the clinical situation but generally acceptable intervals for INR determinations are 1 to 4 weeks .
Perform additional coumadin INR tests when other warfarin products are interchanged with COUMADIN, as well as whenever other medications are initiated, discontinued, or taken irregularly .
Heparin, a common concomitant drug, increases the INR [see Conversion From coumadin Other Anticoagulants and DRUG INTERACTIONS] .

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