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Drug interactions

Based on the mechanism of action of tramadol and the potential for serotonin syndrome, caution is advised when ULTRAM® tramadol is coadministered with a triptan .
If concomitant treatment of ULTRAM® with a tramadol triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome) .
Use With Carbamazepine Patients taking tramadol carbamazepine may have a significantly reduced analgesic effect of ULTRAM® .
Because carbamazepine increases tramadol tramadol 50 mg pra que serve tramadol classification uk 2016 tramacet withdrawal tramadol controlled metabolism and because of the seizure risk associated with tramadol, concomitant administration of ULTRAM® and carbamazepine is not recommended .
Use With Quinidine Tramadol is metabolized to M1 tramadol 50mg lääke tramadol withdrawal klonopin tramadol hydrochloride usp tramadol hcl recommended by CYP2D6 .
Quinidine is a selective inhibitor of that isoenzyme, so that concomitant administration tramadol of quinidine and ULTRAM® results in increased concentrations of tramadol and reduced concentrations of M1 .
The clinical tramadol consequences of these findings are unknown .
In vitro tramadol drug interaction studies in human liver microsomes indicate that tramadol has no effect on quinidine metabolism .
Potential for Other Drugs to Affect Tramadol In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as tramadol high onset order tramadol tramadol hcl look like tramadol no withdrawal symptoms tramadol fluoxetine, paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol .
Administration of CYP3A4 inhibitors, such as ketoconazole and erythromycin, or inducers, such as rifampin tramadol and St .

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