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Respiratory Depression: At high doses or in sensitive patients, hydrocodone may produce dose-related respiratory depression by acting directly on the brain hydrocodone stem respiratory center .
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Head Injury and Increased Intracranial Pressure: The respiratory depressant effects of narcotics and their capacity to elevate hydrocodone cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a preexisting increase in intracranial pressure .
Furthermore, narcotics produce adverse reactions, which may obscure the clinical course hydrocodone of patients with head injuries .
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Misuse, Abuse, and Diversion of Opioids: VICODIN tablets contains hydrocodone, an opioid agonist, and is a Schedule hydrocodone III controlled substance .
Opioid agonists have the potential for being abused and are sought by abusers and people with hydrocodone addiction disorders, and are subject to diversion .
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