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Drug Name  | Mechanism of Action and Pharmacokinetics  | Indications and Status  | Adverse Effects  | Dosing  | Administration Guidelines  | Special Precautions  | Interactions  | Recommended Clinical Monitoring  | Supplementary Public Funding  | purinethol References  | Disclaimer   SYNONYM(S):   6-mercaptopurine; 6-MP; NSC 755 COMMON TRADE NAME(S):   Purinethol® (Teva) B – Mechanism of Action and Pharmacokinetics Mercaptopurine has been in clinical use for over 30 years . purinethol metabolites purinethol haaruitval side effects from purinethol purinethol dosering crohn It is a 6-thiopurine analogue of the naturally occurring purine bases hypoxanthine and guaninehn and acts as a cytotoxic antimetabolite .
purinethol Mercaptopurine requires intracellular anabolism by hypoxantine guanine phosphoribosyl transferase (HGPTPT) to be cytotoxic . dosering purinethol bij crohn purinethol medicine mercaptopurine side effects rash purinethol bij Cytotoxicity is cell cycle phase-specific (S-phase) . purinethol breastfeeding purinethol graviditet purinethol handling purinethol et rectocolite Intracellular activation results in de novo inhibition of purine synthesis and incorporation into DNA .
Bioavailability is 5-37% largely due to first pass metabolism in the liver (less when given with food)   purinethol  Widely distributed to body tissues . oral: Incomplete and variable absorption ± purinethol leukemia purinethol prescribing information purinethol price in india purinethol pi 50% .
Cross blood brain barrier? purinethol Negligible with conventional doses .
Inactivated by TMPT and xanthine purinethol Any use of the information is subject, at all times, to CCO’s Terms and Conditions .

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