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RXFILES TRIAL SUMMARY D SHMYR, L KOSAR MARCH 2016 plavix WWW . CA PLATO: Ticagrelor in Acute Coronary Syndrome 1 PLATelet inhibition and patient Outcomes trial  Patients with a high risk plavix of thrombosis & low risk of bleeding may benefit from ticagrelor .
Caution plavix in those with a history of COPD, asthma, HF, gout & severe renal impairment due to increased risk of dyspnea & elevated serum uric acid & creatinine .
 In PLATO, ACS patients ~60% NSTEACS who received ticagrelor + ASA, versus clopidogrel + ASA, for a median of 9 months had: – ↓ risk composite of death from vascular causes, MI, stroke (NNT=53)  Individual components of the composite: vascular death (NNT=91), MI (NNT=91), stroke (NS) – ↑ risk of non-CABG related major bleeding (NNH=167) & intracranial fatal bleeding, NNH=1112 ; but a ↓ in non-intracranial side effects of plavix and lipitor plavix class action plavix metabolism plavix 75 mg generic name fatal bleeding NNT=500 .
There was plavix an ↑ risk of dyspnea (NNH=17), & premature discontinuation of therapy (NNH=53) .
 Based on the PLATO results, the 2012 Canadian Cardiovascular Society Antiplatelet Guidelines recommend the following:2 plavix Ticagrelor + ASA 81mg daily is preferred over clopidogrel + ASA 81mg daily x 12 months for: – STEMI with primary PCI Strong Recommendation, Moderate-Quality Evidence – NSTEACS (medical management or revascularization) Strong Recommendation, High-Quality Evidence  At time of publication, ticagrelor BRILINTA   $108/month vs clopidogrel PLAVIX, g  $26/month .
BACKGROUND 1,2,3,4,5,6,7,8,9  Dual plavix antiplatelet therapy (DAPT, i .
ASA can plavix cause dizziness plavix and prilosec warning plavix side effects plavix alternative plavix + clopidogrel/prasugrel/ticagrelor) is recommended after ACS (STEMI or NSTEACS) to reduce the risk of thrombosis .

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