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nz keyword: oxycodone – Place in therapy ■■ Oxycodone is a strong opioid and is a second line option oxycodone (after morphine) for use at step three on the WHO analgesic ladder ■■ Morphine remains the first-line strong opioid and oxycodone should be reserved for specific situations ■■ Oxycodone can be considered if morphine is poorly tolerated ■■ Oxycodone is not a substitute for codeine at step two on the analgesic ladder .
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Oxycodone is more expensive than morphine, has a similar side effect profile and there is no clinical evidence to support its oxycodone use firstline .
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