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Drugs administered (n) Dosage and frequency Intrathecal morphine (56) 20 mg SR at 0 h; thereafter, 10 mg IR every 6 h for 24 h 100 µg at spinal anaesthesia Elective cardiac Oral opioid (Oxycodone/ IV PCA morphine (26) 18 mg oxycodone every 12 h + 5 mg per 30 min as needed oxycodone respective groups Radical retropubic Oxycodone – multimodal Oxycodone 10 mg every 12 h (plus bupivacaine, paracetamol, morphine 2 mg/mL; 4–12 mL/h (plus paracetamol, morphine on demand) Epidural – ropivacaine (20) CR oxycodone (16) IV Tramadol/metamizol 10 mg post-op and 10 mg after 12 h 100 mg/1 g every 4 h up to 24 h Oxycodone/acetaminophen (study medication was given to patients experiencing moderate to severe postoperative pain) Gammaitoni Dental surgery Oxycodone/acetaminophen CR oxycodone (61) (study medication was given to patients experiencing moderate to severe postoperative pain) CR, controlled-release; IR, immediate release; PCA, patient controlled analgesia; SR, sustained-release Main Findings by Surgical Setting Abdominal Surgery Laparoscopic abdominal surgery Fanelli and colleagues (23) investigated the preoperative administration of CR oxycodone as a transition opioid from an intraoperative remifentanil infusion for pain control after laparoscopic cholecystectomy (Table 2) .
Compared with placebo, CR oxycodone treatment (10 mg ≥ 60 years old or 20 mg < 60 years old, one hour before surgery and 12 hours after first administration) resulted in a 50% or greater reduction in pain scores, more than 50% reduction in rescue analgesic oxycodone (tramadol) use, and a shorter time to discharge from the recovery room and from the surgical ward .prandingaweg 1 oosterwolde |
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