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CLINICAL PHARMACOLOGY Pharmacodynamics The mechanism of action of fluvoxamine maleate in obsessive compulsive disorder is presumed to be linked to its specific serotonin reuptake inhibition in brain luvox neurons .
Receptor binding studies have demonstrated that fluvoxamine is a potent serotonin reuptake luvox inhibitor in vitro as well as in vivo .
In preclinical studies, it was luvox reviews side effects luvox gad luvox contraindications luvox cr 150 mg luvox y fertilidad found that fluvoxamine inhibited neuronal uptake of serotonin .
In in vitro studies fluvoxamine maleate had no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, luvox or dopaminergic receptors .
Antagonism of some of these receptors is thought luvox dosing luvox racing thoughts zoloft vs luvox for ocd luvox other uses luvox jaw clenching to be associated with various sedative, cardiovascular, anticholinergic, and extrapyramidal effects of some psychotropic drugs .
Pharmacokinetics Bioavailability: The absolute bioavailability of fluvoxamine maleate is luvox 53% .
Oral bioavailability is not significantly luvox affected by food .
In a dose proportionality study involving fluvoxamine maleate at 100, 200 and 300 mg/day for 10 consecutive days in 30 normal volunteers, steady state was achieved after about a luvox week of dosing .
Maximum plasma concentrations at steady state occurred within luvox 3-8 hours of dosing and reached concentrations averaging 88, 283 and 546 ng/mL, respectively .
Thus, fluvoxamine had nonlinear pharmacokinetics over this dose range, luvox i . , higher doses of fluvoxamine maleate produced disproportionately higher concentrations than predicted from the luvox quanto custa luvox antidepressant luvox and zanaflex fluvoxamine (luvox) for ocd luvox pdf lower dose .

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