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Contraindications/Warnings/Precautions: • Prolongation of QT interval; avoid concurrent use with other drugs that prolong QT interval and in patients with risk factors for torsades de pointes (hypokalemia, significant bradycardia, cardiomyopathy) • Patients with glucose 6-phosphate dehydrogenase deficiency • Diabetes mellitus; disturbances of blood glucose have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent or with insulin Drug Interactions: Divalent cations: aluminum, magnesium zinc, iron, calcium, antacids, sucralfate – reduced bioavailability noroxine prévention infection liquide d’ascite noroxin quando fa effetto norfloxacin compendium of quinolones (can cause therapeutic failure) Theophylline, caffeine, xanthines: clearance of these is inhibited with fluoroquinolones Category C: Risk unknown .
Human studies norfloxacin dose rate noroxin for sinus infection metronidazole and norfloxacin norfloxacin nom inadequate .
Monitoring Requirements: Therapeutic: Culture and sensitivities, signs and symptoms of infection Toxic: Urinalysis, BUN, Creatinine, AST and ALT, Physicial examination: encephalopathic Brand names/Manufacturer: noroxin CHIBROXIN (Merck Sharp & Dohme – BRAZIL, SINGAPORE, CHILE, MALAYSIA, USA – Opthalmic solution) FLOXEN (Pharmaniaga – MALAYSIA, HONG KONG) JANACIN (Biolab – THAILAND, HONG KONG, MALAYSIA) LEXINOR (AstraZeneca – SWEDEN, HONG KONG, THAILAND, FINLAND, MALAYSIA) NOROXIN (Merck Sharp & Dohme – SOUTH AFRICA, SWITZERLAND, PORTUGAL, MEXICO, NEW ZEALAND, AUSTRALIA, CHILE, CANADA) ZOROXIN (Merck Sharp & Dohme – BELGIUM, AUSTRIA, DENMARK) .
Antibiotic Class: Antimicrobial Spectrum: Gram positive bacteria: methicillin-susceptible Staphylococcus epidermidis, Staphylococcus Gram negative noroxin bacteria: Enterobacteriaceae, H .

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