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lyrica The drug interaction studies described in this section were conducted in healthy adults, and across various patient populations .
The pharmacokinetic interactions of pregabalin and gabapentin were investigated in 12 healthy lyrica subjects following concomitant single-dose administration of 100-mg pregabalin and 300-mg gabapentin and in 18 healthy subjects following concomitant multiple-dose administration of 200-mg pregabalin every 8 hours and 400-mg gabapentin every 8 hours .
Gabapentin pharmacokinetics following single- and multiple-dose administration were unaltered lyrica by Reference ID: 2962909 pregabalin coadministration .
The extent of pregabalin absorption was unaffected by gabapentin coadministration, although there was a small reduction in rate of lyrica absorption .
Oral Contraceptive Pregabalin coadministration (200 mg three times a day) had no effect on the steady-state pharmacokinetics of norethindrone and ethinyl estradiol (1 mg/35 µg, respectively) in healthy Multiple-dose administration lyrica of pregabalin (300 mg twice a day) in healthy subjects had no effect on the rate and extent of lorazepam single-dose pharmacokinetics and single-dose administration of lorazepam (1 mg) had no effect on the steady-state pharmacokinetics of Multiple-dose administration of pregabalin (300 mg twice a day) in healthy subjects had no effect on the rate and extent of oxycodone single-dose pharmacokinetics .

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