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The lowest dose was well At the high dose the following changes were seen: weight gain was reduced by about 30% in both sexes; plasma protein levels were elevated at 3 and 6 months in the males and throughout the zopiclone study in the females; albumin and globulin levels were elevated; thyroid weights were increased in male rats, accompanied by thyroid hyperplasia and, in some rats, by follicular adenomas; liver weights were increased in female rats both at 6 and 18 months; hepatocellular hypertrophy occurred in both sexes .
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BUN values were increased at all doses in a dose-related fashion; liver function tests were somewhat zopiclone elevated .
Six-month oral study Six dogs/sex/dose received zopiclone seven days per week at doses of order dopareel 10 imovane nz zopiklon lék imovane konstig smak i munnen zopiclone vs ambien stilnoct 0, 5, 10 and 25 mg/kg .
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