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Management diazepam of the symptoms of alcohol withdrawal .
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Depresses diazepam the CNS, probably by potentiating GABA, an inhibitory neurotransmitter .
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Metabolism and Excretion: diazepam Highly metabolized by the hepatic P450 enzymes (CYP2C19 and CYP3A4); the CYP2C19 enzyme system exhibits genetic polymorphism; 15– 20% of Asian patients and 3– 5% of Caucasian and Black patients may be poor metabolizers and may have significantlyqdiazepam concentrations and an ⫽ Canadian drug name .

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