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In a conflict model in Rhesus monkeys, a profile consistent with a separation between doses that induce anxiolytic effects and those having lunesta sedative-motor effects was observed for eszopiclone, being the anxiolytic effect observed at doses lower than the sedative effect .
The affinities of (S)-DMZ and N-oxide zopiclone (two major metabolites) to the central BZD receptor lunesta site were > 20-fold and >250-fold lower than (S)-zopiclone .
(S)-DMZ was shown to enhance GABAA current by increasing the affinity of receptors for GABA but lunesta dose dependently inhibited agonist evoked currents at both NMDA (glutamate) and nACh (acetylcholine) receptors, an effect that was mimicked by zopiclone .
Inhibitory actions at NMDA and nACh receptors are also evident at a 20 μM, a concentration 900-fold higher than the lunesta withdrawal lunesta consumer reviews lunesta and pregnancy lunesta side effects hair loss eszopiclone’s Ki at the central benzodiazepine site [22 nM] .
At this concentration, lunesta zopiclone potentiated GABA-evoked currents from GABA-A receptors by up to 787% (Fleck, 2002) .
Based on the presented data the hypothesis that (S)-zopiclone is the primary component of lunesta vs benzodiazepine ambien vs lunesta half life generic for lunesta in canada lunesta dosage Zopiclone responsible for its efficacy is considered acceptable .
However based on the in lunesta buy lunesta is a controlled substance lunesta reactions lunesta for sleep lunesta class vitro and in vivo it is not demonstrated that removal of the (R)-enantiomer alters either the safety or efficacy at clinically It is asserted that the (S)-zopiclone is the primary component responsible for the pharmacological activity of zopiclone and that the (R) component does not add significant benefit .

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