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Dopamine antagonist, antiemetic Mechanism of Action Domperidone is a dopamine antagonist (blocking both D1 and Dopamine antagonism motilium stimulates gastric emptying, increased rate of intestinal transit time and enhanced strength of oesophageal sphincter contractions .
The antiemetic effect of domperidone is due to the prokinetic effect on the gastrointestinal tract combined with antagonisation of dopamine receptors in the domperidone motilium 10mg motilium usa motilium for constipation motilium for breast milk supply chemo trigger Domperidone does not readily cross the blood brain barrier .

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