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    USE EXTRA CAUTION: • Methadone: the conversion factor increases at Do not use the calculated dose in MMEs to determine dosage for converting one opioid to another—the new opioid should be lower morphine to avoid unintentional overdose caused by incomplete cross-tolerance and individual differences in opioid pharmacokinetics .
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    • Fentanyl: dosed in mcg/hr instead of mg/day, and absorption is affected by heat and other factors HOW SHOULD PROVIDERS USE THE TOTAL DAILY OPIOID DOSE IN CLINICAL PRACTICE? Use caution when prescribing opioids at any dosage and prescribe the lowest morphine mg morphine liquid storage morphine nursing implications morphine vs ms contin morphine effective dose .
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