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Precautions

Liver function tests may be advisable more frequently in patients who are receiving mercaptopurine with other hepatotoxic drugs or with known pre-existing liver purinethol disease .
The onset of clinical jaundice, hepatomegaly, or anorexia with tenderness in the right hypochondrium are immediate indications purinethol drug purinethol ilac purinethol crohn’s disease reviews purinethol leukemia purinethol for withholding mercaptopurine until the exact etiology can be identified .
Likewise, any evidence Reference ID: 2953022 of deterioration in liver purinethol function studies, toxic hepatitis, or biliary stasis should prompt discontinuation of the drug and a search for an etiology of the hepatotoxicity .
The concomitant administration purinethol of mercaptopurine with other hepatotoxic agents requires especially careful clinical and biochemical monitoring of hepatic function .
Combination therapy involving mercaptopurine with other drugs not felt to be hepatotoxic should nevertheless purinethol be approached with caution .
The combination of mercaptopurine with doxorubicin was reported to be hepatotoxic in 19 of 20 patients purinethol undergoing remission-induction therapy for leukemia resistant to previous therapy .
Immunosuppression Mercaptopurine recipients may manifest decreased cellular hypersensitivities purinethol and decreased allograft rejection .
Induction of immunity to infectious agents or vaccines will be subnormal purinethol in these patients; the degree of immunosuppression will depend on antigen dose and temporal relationship to drug .
This immunosuppressive effect should be carefully considered with regard to purinethol intercurrent infections and risk of subsequent neoplasia .
Pregnancy Category D Mercaptopurine can cause fetal harm when purinethol para que serve purinethol overdose symptoms purinethol drug class purinethol maladie de administered to a pregnant woman .

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