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Severe myelosuppression has been reported following concomitant administration of a pro-drug of mercaptopurine and ribavirin; therefore concomitant administration of ribavirin and PURI-NETHOL is not advised (see Myelosuppressive agents When PURI-NETHOL is combined with other myelosuppressive agents, caution should be used; dose reductions may be needed based on haematological monitoring (see Allopurinol/oxipurinol/thiopurinol Xanthine oxidase activity is inhibited by allopurinol, oxipurinol and thiopurinol, which results in reduced conversion of biologically active 6-thioinosinic acid to biologically inactive 6-thiouric When allopurinol, purinethol oxipurinol and/or thiopurinol and mercaptopurine are administered concomitantly it is essential that only a 25% of the usual dose of mercaptopurine is given (see DOSAGE AND ADMINISTRATION) since allopurinol decreases the rate of catabolism of PURI-NETHOL TABLETS – Product Information Aminosalicylates Inhibition of the anticoagulant effect of warfarin when given with mercaptopurine, has been There is in vitro and in vivo evidence that aminosalicylate derivatives (e .
olsalazine, mesalazine or sulphasalazine) inhibit purinethol pi purinethol gelenkschmerzen purinethol buy online purinethol morbus crohn purinethol the TPMT enzyme .
Therefore, lower doses of PURINETHOL purinethol may need to be considered when administered concomitantly with aminosalicylate derivatives (see PRECAUTIONS) .
Following unregulated consumption of salicylates, sulphonamides or undefined tranquillisers by patients receiving mercaptopurine therapy, a slower onset of pancytopenia has been Effect of PURI-NETHOL on other drugs purinethol online kaufen purinethol autoimmune hepatitis purinethol et grossesse purinethol fever Inhibition of the anticoagulant effect of warfarin and acenocoumarol has been reported when co-administered with PURI-NETHOL; therefore higher doses of the anticoagulant may be needed .

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