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mirabilis)400 mg PO every 12 hr noroxin x 3 days Uncomplicated UTI: (other organisms) 400 mg ORALLY every 12 hr x 7-10 days Efficacy and safety not established in patients less than 18 years of age Disease state based dosing: Renal failure of CrCl < 30ml/min: 400mg PO q24h Hepatic failure: No dosing changes recommended at this time .
Contraindications/Warnings/Precautions: • Prolongation of QT interval; avoid concurrent use with other drugs that norfloxacin for noroxin antibiotic noroxin compresse norfloxacin dose per day noroxine eureka prolong QT interval and in patients with risk factors for torsades de pointes (hypokalemia, significant bradycardia, cardiomyopathy) • Patients with glucose 6-phosphate dehydrogenase deficiency • Diabetes mellitus; disturbances of blood glucose have been reported, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent or with insulin Drug Interactions: Divalent cations: aluminum, magnesium zinc, iron, calcium, antacids, sucralfate – reduced bioavailability of quinolones (can cause therapeutic failure) Theophylline, caffeine, xanthines: clearance of these is inhibited with fluoroquinolones Category C: Risk unknown .
Human studies noroxin inadequate .
Monitoring Requirements: Therapeutic: Culture and sensitivities, signs and symptoms of infection Toxic: Urinalysis, BUN, Creatinine, AST and ALT, Physicial examination: encephalopathic Brand names/Manufacturer: CHIBROXIN (Merck Sharp & Dohme – BRAZIL, SINGAPORE, CHILE, MALAYSIA, USA – Opthalmic solution) FLOXEN (Pharmaniaga – MALAYSIA, HONG KONG) JANACIN (Biolab – THAILAND, HONG KONG, MALAYSIA) LEXINOR (AstraZeneca – SWEDEN, noroxine vidal noroxin cystite norfloxacine rcp norfloxacin wikipedia noroxin oz norfloxacin dose HONG KONG, THAILAND, FINLAND, MALAYSIA) NOROXIN (Merck Sharp & Dohme – SOUTH AFRICA, SWITZERLAND, PORTUGAL, MEXICO, NEW ZEALAND, AUSTRALIA, CHILE, CANADA) ZOROXIN (Merck Sharp & Dohme – BELGIUM, AUSTRIA, DENMARK) .

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