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Food has no effect on provigil overall PROVIGIL bioavailability; however, time to reach peak concentration (tmax) may be delayed by approximately one hour if taken PROVIGIL has an apparent volume of distribution of approximately 0 . provigil 9 L/kg .
In human plasma, in vitro, modafinil cost costco provigil vs caffeine generic modafinil costco provigil canada purchase online modafinil is moderately bound to plasma protein (approximately 60%), mainly to albumin .
The potential for interactions of PROVIGIL with highly protein-bound drugs provigil is considered to be minimal .
Metabolism and Elimination The major route of elimination is metabolism (approximately 90%), primarily by modafinil dosage recommendations modafinil coupon cvs provigil generic date provigil online pharmacy the liver, with subsequent renal elimination of the metabolites .
Urine alkalinization has no effect on the elimination provigil of modafinil .
Metabolism occurs through hydrolytic deamidation, S-oxidation, aromatic ring provigil hydroxylation, and glucuronide conjugation .
Less than 10% of an administered dose provigil is excreted as the parent compound .
In a clinical study using radiolabeled modafinil, a total of 81% of the administered radioactivity was recovered in provigil 11 days post-dose, predominantly in the urine (80% vs .
The largest fraction of the drug in urine was modafinil acid, but at least six other provigil metabolites were present in lower concentrations .
, modafinil acid and modafinil provigil sulfone . Only two metabolites reach appreciable concentrations in provigil plasma, i .
In preclinical models, modafinil acid, modafinil sulfone, 2-[(diphenylmethyl)sulfonyl]acetic acid and 4-hydroxy modafinil, were inactive or did not appear to mediate the arousal effects of provigil modafinil .

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