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Since, at present the patient is receiving diazepam, which is closely related to clobazam, it is less likely that clobazam could contribute to such tegretol a reaction .
[8] In tegretol the present case, the patient developed hypersensitivity reaction to two structurally different antiepileptics . The causal relationship was established and we conclude that the reaction can be put tegretol in the category of probable/likely adverse drug reaction with carbamazepine and valproate as it is unlikely to be attributed to concurrent disease or other drugs or chemicals, and which follows a clinically reasonable response on withdrawal (dechallenge) .
Hence physicians while prescribing alternative drugs in case of hypersensitivity reaction to the first line antiepileptics should keep in mind the possibility of cross reactivity between structurally unrelated antiepileptics like tegretol carbamazepine and sodium B .
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