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Precautions

Neoplasms benign, malignant and unspecified (including cysts and polyps) secondary leukaemia and myelodysplasia; hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease (an unlicensed indication) when used in combination with anti-TNF agents has been purinethol reported very rarely (see PRECAUTIONS) .
Blood purinethol vidal purinethol krebs purinethol ou imurel purinethol administration purinethol tableti and lymphatic system disorders Very common: bone marrow suppression; leucopenia and thrombocytopenia .
The dosering purinethol bij crohn purinethol sonne purinethol overdose purinethol tablete cena main side effect of treatment with mercaptopurine is bone marrow suppression leading to leucopenia and thrombocytopenia .
Immune system disorders purinethol Hypersensitivity reactions with the following manifestations have been reported .
arthralgia; skin rash; drug fever Metabolism and nutrition disorders Uncommon: anorexia Gastrointestinal disorders nausea; vomiting; pancreatitis in the IBD population (an unlicensed indication) oral ulceration; intestinal ulceration; pancreatitis (in the licensed indication) purinethol valor purinethol fatigue purinethol glaxosmithkline purinethol colit purinethol Hepatobiliary disorders biliary stasis; hepatotoxicity hepatic necrosis Mercaptopurine is hepatotoxic in animals and humans .
The histological findings in humans purinethol have shown hepatic necrosis and biliary stasis .
5 purinethol mg/kg bodyweight daily is exceeded . PURI-NETHOL TABLETS purinethol – Product Information The incidence of hepatotoxicity varies considerably and can occur with any dose, but more frequently when the recommended dose of 2 .
Monitoring of liver function tests may allow early purinethol detection of liver toxicity .
This is usually reversible if mercaptopurine purinethol therapy is stopped soon enough .

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