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Racemic citalopram was mutagenic in the in vitro bacterial reverse mutation assay (Ames test) in 2 lexapro of 5 bacterial strains (Salmonella TA98 and TA1537) in the absence of metabolic activation .
It was clastogenic in the in vitro Chinese hamster lung cell assay for chromosomal aberrations how long for lexapro to work is lexapro and escitalopram the same lexapro rx how long can i take in the presence and absence of metabolic activation .
Racemic citalopram was not mutagenic in the in vitro mammalian lexapro 10 mg what is a lexapro lexapro information what are the side effects of lexapro is lexapro forward gene mutation assay (HPRT) in mouse lymphoma cells or in a coupled in vitro/in vivo unscheduled DNA synthesis (UDS) assay in rat liver .
It was not clastogenic in the in vitro chromosomal aberration assay in human lymphocytes or in two lexapro in vivo mouse micronucleus assays .
Impairment of Fertility When racemic citalopram was administered orally to 16 male and 24 female rats prior to and throughout mating and gestation at lexapro doses of 32, 48, and 72 mg/kg/day, mating was decreased at all doses, and fertility was decreased at doses ≥ 32 mg/kg/day .
Gestation duration was increased at 48 Pregnancy Category C In a rat embryo/fetal development study, oral administration of escitalopram (56, 112, or 150 mg/kg/day) to pregnant animals during the period of organogenesis resulted in decreased fetal body weight and associated delays in ossification at the two higher doses (approximately ≥ 56 times the maximum recommended human dose [MRHD] lexapro of 20 mg/day on a body surface area [mg/m2] basis) .
Maternal toxicity (clinical signs and decreased body weight gain and food consumption), mild at 56 mg/kg/day, lexapro was present at all dose levels .
The developmental no-effect dose of 56 mg/kg/day is approximately 28 times the MRHD on a mg/m2 lexapro basis .

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