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Avoid the use of DESYREL in combination with other drugs known to prolong desyrel QTc [see Warnings and Precautions (5 .
Class 1A antiarrhythmics: quinidine, procainamide, disopyramide; Class 3 antiarrhythmics: amiodarone, sotalol; Antipsychotics: ziprasidone, chlorpromazine, thioridazine; Antibiotics: gatifloxacin 8 USE IN SPECIFIC POPULATIONS Teratogenic Effects Pregnancy Category C Trazodone hydrochloride has been desyrel shown to cause increased fetal resorption and other adverse effects on the fetus in the rat when given at dose levels approximately 6 to 9 times the maximum recommended human dose (MRHD) of 400 mg/day on mg/m in Reference ID: 4119349 adolescents .
There was also an increase desyrel in congenital anomalies in the rabbit at approximately 6 to 17 times the MRHD on mg/m basis in adolescents .
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