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A carcinogenicity study eszopiclone was also performed in which CD-1 mice were given eszopiclone at doses up to 100 mg/kg/day by oral gavage; although this study did not reach a maximum tolerated dose, and was thus inadequate for overall assessment of carcinogenic potential, no increases in either pulmonary or skin tumors were seen at doses producing plasma levels of eszopiclone estimated to be 90 times those in humans receiving the MRHD — i . , 12 times the exposure in the racemate eszopiclone bcs class lunesta vs xanax lunesta on drug test lunesta and high blood pressure common study .
Eszopiclone did not increase tumors in a p53 transgenic mouse lunesta vs klonopin lunesta weird side effects lunesta youtube eszopiclone online pharmacy lunesta bioassay at oral doses up to Eszopiclone was positive in the mouse lymphoma chromosomal aberration assay and produced an equivocal response in the Chinese hamster ovary cell chromosomal aberration assay .
It was eszopiclone not mutagenic or clastogenic in the bacterial Ames gene mutation assay, in an unscheduled DNA synthesis assay, or in an in vivo mouse bone marrow micronucleus assay .
(S)-N-desmethyl zopiclone, a eszopiclone metabolite of eszopiclone, was positive in the Chinese hamster ovary cell and human lymphocyte chromosomal aberration assays .
It was negative in the bacterial Ames mutation assay, in an in vitro 32P-postlabeling DNA adduct assay, and in an in vivo eszopiclone mouse bone marrow chromosomal aberration and micronucleus assay .
Impairment Of Fertility Eszopiclone was given by oral gavage to male rats at doses up to 45 mg/kg/day from 4 weeks premating through mating and to female side effects of lunesta 3 eszopiclone dose range lunesta kidney problems lunesta generic price rats at doses up to 180 mg/kg/day from 2 weeks premating through day 7 of pregnancy .
An additional study was performed in which only females were eszopiclone treated, up to 180 mg/kg/day .

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