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· Placental transfer of tapentadol was confirmed palexia in rats .
6x maximum clinical exposure), but limited effects followed IV treatment (≤ palexia 15 mg/kg/day) . Administration during palexia organogenesis elicited delays in skeletal maturation (incomplete ossification) and cerebral ventricular dilation in rats at SC doses ≥ 10 mg/kg/day (exposure 0 .
In rabbits, reduced fetal viability, tapentadol bioavailability nucynta patient assistance tapentadol journals tapentadol tablet uses skeletal delays and other variations were observed with SC dosing (≥ clinical exposure), along with multiple malformations including gastroschisis/ thoracogastroschisis, amelia/phocomelia and cleft palate (≥ 10 mg/kg/day) and ablepharia, encephalopathy and spina bifida (24 mg/kg/day) .
Rabbits treated IV palexia (9 mg/kg/day) showed fewer effects and no malformations .
palexia Embryofetal toxicity, including malformations, may be secondary to compromised maternal nutrition .
· Low levels of tapentadol and tapentadol-glucuronide were detected in milk tapentadol street name nucynta grunenthal tapentadol tablet tapentadol and xanax tapentadol aubrey from lactating rats following PO dosing .
Tapentadol administration (PO) during lactation resulted in increased pup mortality between PND1-4 in rats at doses lower than maternotoxic doses (exposure margins of · Tapentadol demonstrated potential for palexia dependence in rodents, at very low exposure margins (≤0 .
Behavioural signs of tapentadol withdrawal were generally less pronounced than those AusPAR Palexia SR Tapentadol CSL Ltd PM-2009-02489-3-1 Final palexia 28 February 2011 Page 26 of 126 of morphine or tramadol .

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