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pseudoephedrine, norephedrine, amphetamine, ephedrine, and estrogen (Tables adipex 1 and 3) .
Most of these compounds are also reversible MAO inhibitors, and when two or more are combined, their effects on MAO adipex night eating what is duromine used for ionamin 37.5 adipex 37.5 and exercise adipex weight are additive (Table 3) .
The fact that the effects of reversible MAO inhibitors are additive bears on the adipex possible consequences, among obese European patients, of having taken both a fenfluramine and a multi-drug “compounded preparation” that frequently contained numerous MAO inhibitors, including amphetamine-like compounds [18] .
The effects of unrecognized MAO inhibitors on pulmonary serotonin metabolism might also explain the tendency of fenfluramine-associated valvular lesions to affect the left side of the heart [1]—in contrast to the right-sided lesions found in patients with the carcinoid syndrome—as well as the reported association between fenfluramine use and primary pulmonary hypertension [18]: Most circulating serotonin is cleared in the lung, through adipex metabolism by MAO [16] .
In the carcinoid patient, pulmonary MAO is still active, so plasma serotonin concentrations in the right side of the heart are greater than those in the left side; however, as discussed above, in patients taking an MAO adipex inhibitor the pulmonary clearance of serotonin is inhibited, TABLE 2 .
EC50 values of MAO inhibitors for MAO-A and MAO-B in adipex rat lung and brain homogenates MAO-A and MAO-B activities were assayed and the concentration–inhibition curves obtained for their inhibition by known MAO-A and MAO-B inhibitors in lung and brain homogenates .
The concentration producing 50% adipex inhibition (IC50) was calculated graphically from semi-log plots (the concentration–inhibition curve) of inhibitor concentration against percent inhibition .

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