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    Accumulation alprazolam is minimal .
    Metabolism and Excretion: Metabolized by the liver alprazolam (CYP3A4 enzyme system) to an active compound that is subsequently rapidly metabolized .
    TIME/ACTION PROFILE (sedation) Contraindications/Precautions Contraindicated in: Hypersensitivity; Cross-sensitivity with other benzodiazepines may exist; Pre-existing alprazolam user reviews xanax only alprazolam g3720 xanax uk documentary xanax withdrawal worse CNS depression; Severe uncontrolled pain; Angle-clo⫽ Canadian drug name .
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    Use Cautiously in: Renal impairment(pdose required); Hepatic impairment (p dose required); Concurrent use with nefazodone, fluvoxamine, cimetidine, fluoxetine, hormonal contraceptives, diltiazem, isoniazid, erythromycin, clarithromycin, or grapefruit juice (pdose may be necessary); History of suicide attempt or alcohol/ drug dependence, debilitated patients (pdose required); Pedi: Safety and efficacy not established;pdosage and frequent monitoring required; Geri: Appears on Beers alprazolam list .
    Elderly patients haveqsensitivity to benzodiazepines; associated withqrisk of falls and alprazolam excessive CNS effects (pdose required) .
    ALPRAZolam (al-pray-zoe-lam) Plate # 0-Composite Adverse Reactions/Side Effects CNS: dizziness, alprazolam drowsiness, lethargy, confusion, hangover, headache, mental depression, paradoxical excitation .
    alprazolam GI: constipation, diarrhea, nausea, vomiting, weight gain .
    alprazolam Misc: physical dependence, psychological dependence, tolerance .

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