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2,3 After these analyses, the combination treatment arm was closed because arimidex of low efficacy . Initial arimidex analyses of the ATAC trial at 33 and 47 months of median follow-up showed that anastrozole significantly prolonged disease-free survival and time-to-recurrence, and reduced the incidence of contralateral breast cancer, compared with tamoxifen .
Details of the trial design, methods, primary objectives, and endpoints have been reported Here we compare the efficacy and tolerability of anastrozole with that of tamoxifen after arimidex a median follow-up of 68 months .
This arimidex time extends beyond the planned 5-year treatment period and only 8% of patients remain on trial treatment .
Treatment with anastrozole arimidex estrogen rebound arimidex with testosterone cypionate arimidex toxicity arimidex side led to significant improvements compared with tamoxifen for diseasefree survival (575 vs 651 events, hazard ratio 0·87, 95% CI 0·78–0·97, p=0·01) and time-to-recurrence (402 vs 498, 0·79, 0·70–0·90, p=0·0005) .
A greater advantage was seen in disease-free survival (0·83, 0·73–0·94, anastrozole cycle arimidex hdl anastrozole and grapefruit juice arimidex chemo precautions p=0·005) and in time-to-recurrence (0·74, 0·64–0·87, p=0·0002) in hormone-receptor-positive patients (figure 1A) .

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