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Reductions in maternal weight gain occurred at dosages of 5 mg/kg/day or greater and clonazepam reduction in embryo-fetal growth occurred in one study at a dosage of 10 mg/kg/day .
No adverse maternal or embryo-fetal effects were observed in mice and rats following administration during organogenesis of oral doses up to 15 mg/kg/day or 40 mg/kg/day, respectively (4 and 20 times the maximum recommended human dose of 20 mg/day for seizure disorders and 20 and 100 times the maximum dose of 4 mg/day for panic disorder, respectively, clonazepam on a mg/m2 basis) .
General Concerns and Considerations About Anticonvulsants: Recent reports suggest an association between the use of clonazepam anticonvulsant drugs by women with epilepsy and an elevated incidence of birth defects in children born to these women .
Data are more extensive with respect to diphenylhydantoin clonazepam constipation clonazepam e64 clonazepam generic clonazepam dose in neonates bft clonix and phenobarbital, but these are also the most commonly prescribed anticonvulsants; less systematic or anecdotal reports suggest a possible similar association with the use of all known anticonvulsant drugs .
In clonazepam children of women treated with drugs for epilepsy, reports suggesting an elevated incidence of birth defects cannot be regarded as adequate to prove a definite cause and effect relationship .
There are intrinsic methodologic problems in obtaining adequate data on drug teratogenicity in humans; the possibility also exists that other factors (eg, genetic factors or the epileptic condition itself) may be more important than drug therapy in leading to birth clonazepam defects .
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