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In view of the retinal clonidine degeneration seen in rats, eye examinations were performed during clinical trials in 908 patients before, and periodically after, the start of clonidine therapy .
In 353 of these 908 patients, the eye examinations clonidine were carried out over periods of 24 months or longer .
Except clonidine for some dryness of the eyes, no drug-related abnormal ophthalmological findings were recorded and, according to specialized tests such as electroretinography and macular dazzle, retinal function was unchanged .
In combination with amitriptyline, clonidine hydrochloride clonidine epilepsy clonidine withdrawal side effects ic clonidine clonidine and blood pressure administration led to the development of corneal lesions in rats within 5 days .
Carcinogenesis, Mutagenesis, Impairment of Fertility Chronic dietary administration of clonidine was not carcinogenic to rats (132 weeks) or mice (78 weeks) dosed, respectively, clonidine at up to 46 or 70 times the maximum recommended daily human dose as mg/kg (9 or 6 times the MRDHD on a mg/m2 basis) .
There was no evidence of genotoxicity in the Ames clonidine and children clonidine substitute what is clonidine hcl 0.1 mg used to treat clonidine test for mutagenicity or mouse micronucleus test for Fertility of male or female rats was unaffected by clonidine doses as high as 150 mcg/kg (approximately 3 times MRDHD) .
In a separate experiment, fertility of female rats appeared to be affected at dose levels of 500 clonidine to 2000 mcg/kg (10 to 40 times the oral MRDHD on a mg/kg basis; 2 to 8 times the MRDHD on a mg/m2 basis . ) Teratogenic Effects: clonidine Pregnancy Category C .

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