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Effect on Other coumadin Drugs Coumarins may also affect the action of other drugs .
Hypoglycemic agents (chlorpropamide and tolbutamide) and anticonvulsants (phenytoin and phenobarbital) may accumulate in the body as a result of interference coumadin levels range is coumadin and warfarin the same coumadin blood test therapeutic range of with either their metabolism or excretion .
Considerations for Increased Bleeding Risk COUMADIN coumadin is a narrow therapeutic range (index) drug, and additional caution should be observed when warfarin sodium is administered to certain patients .
Reported risk factors coumadin for bleeding include high intensity of anticoagulation (INR >4 . 0), age ≥65, highly variable INRs, history of gastrointestinal bleeding, hypertension, cerebrovascular disease, serious heart disease, anemia, malignancy, trauma, renal insufficiency, coumadin concomitant drugs (see PRECAUTIONS) and long duration of warfarin therapy .
Identification of risk factors for bleeding and certain genetic variations in CYP2CP and VKORC1 in a patient may increase the need for more frequent INR monitoring and the use of lower warfarin doses (see CLINICAL coumadin toxicity coumadin price is coumadin a anticoagulant coumadin inr does coumadin make you PHARMACOLOGY: Metabolism and DOSAGE AND ADMINISTRATION) .

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