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    Information Sheet Original version: 17/06/2014 Tolerance, dependence and withdrawal: Benzodiazepines such as etizolam which are more rapidly eliminated from the body are less likely to accumulate 17, and there is etizolam evidence to suggest that etizolam is less likely to induce tolerance and dependence compared with classical benzodiazepines 18 .
    However, dependence may etizolam develop with regular use of benzodiazepines, even in therapeutic doses for short periods .
    If benzodiazepines are discontinued abruptly etizolam after regular use, withdrawal symptoms may develop .
    Administration of regular etizolam doses of benzodiazepines can result in physical dependence, characterized by a withdrawal syndrome when the drug is discontinued .
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    Withdrawal symptoms include: anxiety, insomnia, headache, dizziness, tinnitus, anorexia, etizolam vomiting, nausea, tremor, weakness, perspiration, irritability, hypersensitivity to visual and auditory stimuli, palpitations, tachycardia (fast heart rate) and postural hypotension (drop in blood pressure on standing) .
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