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Precautions

The potential of eszopiclone to inhibit human liver CYP450 isoforms 1A2, 2A6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4 was lunesta snort high eszopiclone recreational use eszopiclone dosage lunesta vs ambien ingredients determined in study 190-518 in cryopreserved human hepatocytes in the presence and absence of standard probe substrates, the outcome is shown in Table 6 below .
Table 6: The effect of eszopiclone on CYP450 isoenzymes coumarin 7-hydroxylation chlorzoxazone 6-hydroxylation 7-ethoxyresorufin Odealkylation tolbutamide 4-hydroxylation dextromethorphan Odemethylation Dose dependent inhibition Dose dependent inhibition Dose dependent inhibition Eszopiclone did not cause inhibition of the metabolism of specific substrates of the CYP450 isoforms 1A2, 2A6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4 in human hepatocytes at concentrations up to eszopiclone 100 µM .
This demonstrated that eszopiclone lunesta nz lunesta xanax eszopiclone alternatives lunesta brain fog lunesta generic india was not a CYP450 inhibitor .
The in vitro metabolism of [14C]-eszopiclone was compared in study 190-536 eszopiclone in human hepatocytes in the absence or presence of (R)-zopiclone .
Examination of radio-HPLC chromatograms showed that the radioactivity profiles of [14C]-eszopiclone were eszopiclone very similar between the incubation mixtures with or without (R)-zopiclone, indicating that (R)-zopiclone did not affect the rate of in vitro metabolism of [14C]eszopiclone .
Inter-conversion No interconversion from eszopiclone to (R)-zopiclone was observed in the eszopiclone medscape lunesta benzo lunesta reviews side effects lunesta elimination half life combined bioavailability & bioequivalence Study (Study 190-010) or in Study 190-001 .

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