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However, in a carcinogenicity study in Sprague-Dawley rats in which racemic zopiclone was given in the diet, and in which plasma levels of eszopiclone were reached that were greater than those reached in the above study of eszopiclone, an lunesta high dose dosage for eszopiclone lunesta and generic lunesta side effects memory lunesta increase in mammary gland adenocarcinomas in females and an increase in thyroid gland follicular cell adenomas and carcinomas in males were seen at the highest dose of 100 mg/kg/day .
Plasma levels of eszopiclone at eszopiclone half life lunesta groggy generic lunesta problems lunesta dementia lunesta vs. xanax to this dose are estimated to be 150 (females) and 70 (males) times those in humans receiving the MRHD .
The mechanism for the increase in mammary lunesta vs ambien xr lunesta side effects prostate lunesta generic price lunesta label lunesta adenocarcinomas is unknown .
The eszopiclone increase in thyroid tumors is thought to be due to increased levels of TSH secondary to increased metabolism of circulating thyroid hormones, a mechanism that is not considered to be relevant to humans .
In a carcinogenicity study in B6C3F1 mice in which racemic zopiclone was given in the diet, an increase in pulmonary carcinomas and carcinomas plus adenomas in females eszopiclone and an increase in 21476 FDA approved labeling text 1 . 08 skin fibromas and sarcomas eszopiclone in males were seen at the highest dose of 100 mg/kg/day .
Plasma levels of eszopiclone at this dose are estimated to be 8 eszopiclone (females) and 20 (males) times those in humans receiving the MRHD .
The skin tumors were due to skin lesions induced by aggressive behavior, a mechanism that is eszopiclone not relevant to humans .

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