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It eszopiclone was negative in the bacterial Ames mutation assay, in an in vitro 32P-postlabeling DNA adduct assay, and in an in vivo mouse bone marrow chromosomal aberration and micronucleus assay .
Impairment Of Fertility Eszopiclone was given by oral gavage to male rats at doses up to 45 mg/kg/day from 4 weeks premating through mating and to female rats at doses up to eszopiclone rite aid lunesta tolerance will lunesta knock me out lunesta therapeutic class lunesta 180 mg/kg/day from 2 weeks premating through day 7 of pregnancy .
An additional study was performed in which only females were eszopiclone treated, up to 180 mg/kg/day .
Eszopiclone decreased fertility, probably because of effects in both males and females, with no females becoming pregnant when both males and females were treated with the highest dose; the no-effect dose lunesta uveitis lunesta dreams lunesta vs belsomra lunesta hydrocodone lunesta kidney stones lunesta in both sexes was 5 mg/kg (16 times the MRHD on a mg/m2 basis) .
Other effects included increased pre-implantation loss (noeffect dose 25 mg/kg), abnormal estrus cycles (no-effect dose 25 mg/kg), and decreases in sperm number and motility and increases in morphologically abnormal sperm (no-effect dose 5 eszopiclone hplc method eszopiclone pronounce eszopiclone sales lunesta how does it work lunesta mg/kg) .
Pregnancy Category C Eszopiclone administered by oral gavage to pregnant rats and rabbits during the period of organogenesis showed no evidence of teratogenicity up to the highest doses tested (250 and 16 mg/kg/day lunesta like xanax lunesta prior authorization bad side effects from lunesta lunesta used for in rats and rabbits, respectively; these doses are 800 and 100 times, respectively, the maximum recommended human dose [MRHD] on a mg/m2 basis) .

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