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NSAIDs including MOTRIN tablets, can lead to onset of new hypertension or worsening of pre-existing hypertension, either of which may contribute to the ibuprofen increased incidence of CV events .
Patients taking thiazides or loop diuretics may have impaired response to these therapies ibuprofen when taking NSAIDs .
NSAIDs, including MOTRIN ibuprofen tablets, should be used with caution in patients with hypertension .
Blood pressure (BP) should be ibuprofen monitored closely during the initiation of NSAID treatment and throughout the course of therapy .
Congestive Heart Failure and Edema Fluid retention and edema have been observed in some ibuprofen patients taking NSAIDs .
MOTRIN tablets should ibuprofen be used with caution in patients with fluid retention or heart failure .
Gastrointestinal Effects how often can you take 400mg ibuprofen advil and ibuprofen what are the side effects of taking – Risk of Ulceration, Bleeding, and NSAIDs, including MOTRIN tablets, can cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine, which can be fatal .
These serious adverse events can occur at any time, ibuprofen with or without warning symptoms, in patients treated with NSAIDs .
Only one in five patients, who develop a ibuprofen serious upper GI adverse event on NSAID therapy, is symptomatic .
Upper GI ulcers, gross bleeding, or perforation caused by ibuprofen NSAIDs occur in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year .
These trends continue ibuprofen lysine advil and ibuprofen ibuprofen 800mg overdose therapeutic dose of ibuprofen for with longer duration of use, increasing the likelihood of developing a serious GI event at some time during the course of therapy .

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