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Escitalopram is metabolized via the cytochrome P450 (CYP450) isozymes CYP450 3A4 (35%), 2C19 (37%) and 2D6 (28%) lexapro to S-demethylcitalopram (S-DCT) .
However, ritonavir, a potent inhibitor of 3A4, does not affect lexapro medication side effects escitalopram vs lexapro what does lexapro do lexapro commercial what the pharmacokinetics of escitalopram [16] .
S-DCT is further metabolized to lexapro S-didemethylcitalopram [17] .
Data obtained on synaptosomes lexapro in vitro show that S-DCT is ten times less effective as an inhibitor of serotonin reuptake than escitalopram, but preserves its selectivity for serotonin [3,18] .
If the effect of serotonin reuptake inhibition by citalopram is set to 1, then escitalopram has lexapro a value of 2, S-DCT 0 . 4 and does lexapro work for anxiety is lexapro for depression or anxiety lexapro to prozac lexapro 5mg for S-didemethylcitalopram 0 .
The S-DCT serum level is half that of the maternal compound, and its penetration into the brain is low, so that this metabolite does not contribute lexapro to the clinical effect of escitalopram .
Based on tests with racemic citalopram, other pharmacologically inactive metabolites are known, such as derivatives of propionic acid via metabolism by monoaminoxidase [19], and antidepressant lexapro side effects lexapro drug class are headaches a side effect of lexapro N-oxides and glucuronides [20] .
The formation of S-DCT is reduced when will lexapro work lexapro side effects in women lexapro causing depression lexapro liquid what by approximately 60% by ketoconazole (3A4 inhibitor), by approximately 80% by chinidine (2D6 inhibitor) and by omeprazole (2C19 inhibitor) [21,17] .
Slow 2C19 but not 2D6 lexapro 20 is lexapro safe does lexapro lexapro liquid what is lexapro supposed to do lexapro how metabolizers have higher escitalopram plasma concentrations .
lexapro S-DCT is biodegraded via 2D6 to didemethylcitalopram .

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