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Primary lioresal wirkung intrathecal baclofen dose range lioresal ahumada lioresal controindicazioni Pharmacological Activity: Baclofen depresses monosynaptic and polysynaptic reflex transmission in the spinal cord .
The antispastic activity is derived primarily from its action at the spinal level to reduce spasms in voluntary muscles lioresal (see also LIORESAL* Product Monograph) .
lioresal Secondary Pharmacological Activity: Intrathecal baclofen exerts an antinociceptive effect in rats and cats .
These effects are independent lioresal of any debilitation of voluntary motor function .
lioresal In addition, intrathecal baclofen affects lower urinary tract dynamics of the anesthetized dog .
Vesical and urethral pressure was lioresal significantly decreased .
Within 30 minutes of injection, relaxation of the bladder and a reduction in lioresal urethral resistance occurred .
LD50 values following intrathecal lioresal dosing are not available .
Long-Term Toxicity The oral toxicity of LIORESAL* lioresal has been thoroughly investigated .
LIORESAL* Intrathecal requires the use of much smaller doses to achieve a therapeutic effect, with consequential lower lioresal systemic exposure .
Repeated lioresal dose toxicity Repeated intrathecal administration of baclofen to rats and dogs was not associated with irritation or inflammation of the spinal cord and surrounding tissues .
Inflammation of the spinal cord was observed in one rabbit in a study that administered intrathecal baclofen to 3 rabbits weekly over a period of 3 lioresal to 6 months .
Subacute and lioresal subchronic studies with continuous intrathecal baclofen infusion in two species (rat, dog) revealed no signs of local irritation or inflammation on histological examination .

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