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Drug interactions

Renal impairment No controlled clinical pharmacokinetic study is available in patients with renal impairment after administration of BACLOFEN Baclofen lioresal is predominantly eliminated unchanged in urine .
Sparse plasma concentration data collected in female patients under chronic hemodialysis or compensated renal failure indicate significantly decreased clearance and increased half-life of baclofen lioresal in these patients .
Severe neurological outcomes have been reported in patients with renal impairment after oral lioresal 10 mg lioresal ficha tecnica lioresal retirada lioresal zelfde als baclofen intrathecal administration, thus BACLOFEN should be given with special care and caution in these patients (see WARNINGS, Renal Impairment) .
BACLOFEN (baclofen) is useful for the lioresal upute baclofen intrathecal pump dosage lioresal ultrafarma intrathecal baclofen j code alleviation of signs and symptoms of spasticity resulting from multiple sclerosis .
BACLOFEN may also be of some value in patients with spinal cord injuries and other spinal cord lioresal injection lioresal intrathecal (baclofen injection) package insert intrathecal baclofen CONTRAINDICATIONS Hypersensitivity to BACLOFEN (baclofen) or to any of the excipients .
Abrupt Drug Withdrawal: Following abrupt withdrawal of baclofen, delirium, visual and auditory hallucinations, lioresal medication lioresal intrathecal lioresal withdrawal symptoms lioresal obat untuk lioresal convulsion (status epilepticus), dyskinesia, confusional state, psychotic disorder, mania or paranoia, anxiety with tachycardia and sweating, insomnia, and worsening of spasticity have occurred .
Therefore, except for serious adverse reactions, the dose should be reduced slowly when the drug is discontinued lioresal (over a period of approximately 1-2 weeks) .

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