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The average number of stillbirths or viable newborns did lioresal not differ significantly between control and medicated groups .
The average weight of neonates from the high dose group was lioresal significantly reduced .
Rabbit: lioresal Doses of 1, 5 and 10 mg/kg/day were administered by gavage to groups of rabbits from the 6th to 18th day of gestation .
There was an increased incidence of unossified phalangeal nuclei of forelimbs and hindlimbs lioresal galinos intrathecal baclofen urinary retention lioresal et alcool intrathecal baclofen in the fetuses from the high dose group .
In another study, a slight increase in resorption rates was observed in rabbits receiving 10 and 15 mg/kg/day of oral Baclofen did not cause teratogenic effects in mice, rats, and rabbits at doses lioresal up to125-times the maximum intrathecal mg/kg dose .
LIORESAL* given orally increased the incidence of omphaloceles (ventral hernias) in baclofen intrathecal resistance lioresal en mexico intrathecal baclofen for pain intrathecal fetuses of rats given approximately 500-times the maximum intrathecal dose expressed as a mg/kg dose .
This abnormality was not seen in mice or lioresal rabbits .
lioresal LIORESAL* dosed orally caused delayed fetal growth (ossification of bones) at doses that also caused maternal toxicity in rats and rabbits, and when given intraperitoneally, baclofen at high doses caused widening of the vertebral arch in rat fetuses .
Carcinogenicity studies A 2-year rat study (oral administration) showed that baclofen is not lioresal overdose treatment lioresal over the counter intrathecal baclofen history lioresal usage carcinogenic .
In the same study a dose-related increase in incidence of ovarian cysts and a less marked lioresal increase in enlarged and/or hemorrhagic adrenal glands was observed .voltaren gel side effects liver |
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