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Maintenance dosage for long-term continuous infusion of intrathecal baclofen ranges from 10 μg/day to lioresal 1200 μg/day, most patients being adequately maintained on 300 μg/day to 800 μg/day .
The specific concentration that should be used depends upon the total daily dose required as well intrathecal baclofen for spasticity in cerebral palsy lioresal et valium intrathecal baclofen half as the delivery rate of the pump .
Please consult pump manufacturer’s lioresal manual for specific recommendations .
During long-term treatment approximately 10% of patients become refractory to increasing lioresal doses .
This ‘tolerance’ may be treated by gradually lioresal reducing LIORESAL* Intrathecal dose over a 2 to 4 week period and switching to alternative methods of spasticity management (e .
lioresal intrathecal preservative-free morphine sulfate) .
After a few days the sensitivity to baclofen may be restored and treatment should be resumed at the initial continuous infusion dose and followed by a titration phase to avoid intrathecal baclofen history intrathecal baclofen maximum dose intrathecal baclofen risks lioresal overdose accidents .
This must be performed lioresal in a hospital unit .
Caution should be exercised when switching from LIORESAL* Intrathecal to morphine and vice versa lioresal (see Precautions – Drug Interactions) .
Regular clinical review remains a necessity throughout to assess dosage lioresal requirements, functioning of the delivery system, and monitoring for possible adverse drug reactions or evidence of infection .
Special populations: Renal impairment No studies have been performed in patients with renal impairment lioresal with LIORESAL* Intrathecal therapy .nsaid voltaren,
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