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Number of Subjects Reporting Unpleasant Taste following Administration of Eszopiclone or Racemic Zopiclone both in Oral Solution*(Study 190-001) Pharmacology at lunesta the GABA receptor Based on the EC50 data (study 190-435), racemic zopiclone has its highest potency for α1 and α5 receptors with a potency at α1 that is similar to that of zolpidem .
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4 times less potent than lunesta zolpidem at α1) . eszopiclone lunesta is 3 .
Based on the % maximal current data, racemic zopiclone has its maximal effectiveness at α1 and α5 receptors, whereas eszopiclone has its maximal effectiveness at α2 and lunesta medscape side effects of taking lunesta long term lunesta reviews webmd lunesta vs ambien α3 receptors .
GABA subunit α1 has been implicated in the development lunesta pill side effects lunesta class lunesta manufacturer lunesta and zantac lunesta vs of psychological dependence .
In particular, α1-selective agents zolpidem lunesta and zaleplon, have been demonstrated to be self-administered in nonhuman primates in a way that was greater than benzodiazepines and was in fact comparable to barbiturates .
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According to the applicant, and in relation to the data provided by the above studies, improvement in the benefit risk profile is therefore lunesta attributable to the following differences: 1 .

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