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Other adverse reactions include the following: (listed alphabetically under each Body as a Whole – asthenia (weakness), edema, headache Cardiovascular (also see WARNINGS: Cardiac Conduction Effects) – arrhythmias, bigeminal rhythms, bradycardia, cardiomyopathy, ECG abnormalities, extrasystoles, flushing, heart failure, hypotension, palpitations, phlebitis, QT interval prolongation, syncope, methadone T-wave inversion, tachycardia, torsade de pointes, ventricular fibrillation, ventricular tachycardia NDA 17-116/S-021 Digestive – abdominal pain, anorexia, biliary tract spasm, constipation, dry mouth, glossitis Hematologic and Lymphatic – reversible thrombocytopenia has been described in opioid addicts with chronic hepatitis Metabolic and Nutritional – hypokalemia, hypomagnesemia, weight gain Nervous – agitation, confusion, disorientation, dysphoria, euphoria, insomnia, Respiratory – pulmonary edema, respiratory depression (see WARNINGS: Respiratory Depression) Skin and Appendages – pruritis, urticaria, other skin rashes, and rarely, hemorrhagic urticaria Special Senses – hallucinations, visual disturbances Urogenital – amenorrhea, antidiuretic effect, reduced libido and/or potency, urinary retention or hesitancy Maintenance on a Stabilized Dose – During prolonged administration of methadone, as in a methadone maintenance treatment program, there is usually a gradual, yet progressive, disappearance of side effects over a period of several weeks .
However, constipation and methadone sweating often persist .
DRUG ABUSE AND DEPENDENCE Methadose contains methadone, methadone clinic denver methadone street names methadone rx methadone and suboxone methadone in a potent Schedule II opioid agonist .

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