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Obstructive Sleep Apnea (OSA) The effectiveness modafinil of PROVIGIL in reducing the excessive sleepiness associated with OSA was established in two clinical trials .
In both studies, patients were enrolled who met the International PI + MG October 2010 Classification of Sleep Disorders (ICSD) criteria for OSA (which are also consistent with the American Psychiatric Association modafinil DSM-IV criteria) .
These criteria include either, 1) excessive sleepiness or insomnia, plus frequent episodes of impaired breathing during sleep, and associated features such as loud snoring, morning headaches and dry mouth upon awakening; or 2) excessive sleepiness or insomnia and polysomnography demonstrating one of the following: more than five obstructive apneas, each greater than 10 seconds in duration, per hour of sleep and one or more of the following: frequent arousals from sleep associated with the apneas, bradytachycardia, and arterial oxygen desaturation in association modafinil tbi order modafinil online reddit buy modafinil online cheap modafinil vendors reddit with the apneas .
In addition, for entry into these studies, all patients were required to have excessive sleepiness as demonstrated by a score ≥10 on the Epworth Sleepiness Scale, despite modafinil modalert online modafinil online duck modafinil online from canada modafinil dopamine treatment with continuous positive airway pressure (CPAP) .
Evidence that CPAP was effective in reducing episodes of modafinil apnea/hypopnea was required along with documentation of CPAP use .
In the first study, a 12-week multicenter placebo-controlled trial, a total of 327 patients were randomized modafinil to receive PROVIGIL 200 mg/day, PROVIGIL 400 mg/day, or matching placebo .
The majority of patients (80%) were fully compliant modafinil with CPAP, defined as CPAP use > 4 hours/night on > 70% nights .

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