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The majority of the spontaneous reports reviewed indicated that onset of events was within the first few months of modvigil initiating modafinil, and positive de-challenge or re-challenge was also reported .
The percentage of modvigil patients experiencing a psychiatric adverse event in clinical trials is also significant, particularly when compared to placebo .
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Cardiovascular disorders A review of the MAH’s pharmacovigilance database identified 873 spontaneous reports of cardiovascular disorders, of which 171 were serious and 17 had Acheter modvigil Euro debit Alencon acheter modafinil pendant la nuit modvigil prochain jour acheter a fatal outcome .
This includes 69 events of torsades de pointes/QT acheter modafinil avec bitcoin acheter provigil du canada achat modvigil western union Cenon acheter prolongation, 405 of cardiac arrhythmia, 74 of cardiac failure, 205 of hypertension, 462 of cardiomyopathy and 57 of ischemic heart disease .
Positive de-challenge and/or re-challenge modvigil was reported in some cases .
In the placebo controlled studies, various modvigil cardiovascular events occurred almost exclusively in the modafinil treated group .
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