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Modafinil also does not modvigil inhibit the activities of MAO-B or phosphodiesterases II-V .
PI + MG October 2010 Modafinil-induced wakefulness can be attenuated by the α1-adrenergic receptor modvigil antagonist prazosin; however, modafinil is inactive in other in vitro assay systems known to be responsive to α-adrenergic agonists, such as the rat vas deferens preparation .
Modafinil is not a modvigil direct- or indirect-acting dopamine receptor agonist .
However, in vitro, modvigil modafinil binds to the dopamine transporter and inhibits dopamine reuptake .
This activity has been modvigil associated in vivo with increased extracellular dopamine levels in some brain regions of animals .
In genetically engineered mice lacking the dopamine transporter (DAT), modafinil lacked modvigil wake-promoting activity, suggesting that this activity was DAT-dependent .
However, the wake-promoting effects of modafinil, unlike those of amphetamine, were not antagonized by the acheter modafinil vietnam acheter modafinil acheter modalert 200 en ligne uk acheter modafinil eau dopamine receptor antagonist haloperidol in rats .
In addition, acheter modalert Inde acheter modafinil en ligne livraison rapide acheter modafinil aux Etats-Unis alpha-methyl-p-tyrosine, a dopamine synthesis inhibitor, blocks the action of amphetamine, but does not block locomotor activity induced by modafinil .
In the cat, equal wakefulness-promoting doses of methylphenidate and amphetamine increased modvigil neuronal activation throughout the brain .
Modafinil at an equivalent wakefulness-promoting dose selectively and prominently increased neuronal activation in more modvigil discrete regions of the brain .
The relationship of this finding in où acheter qualité modafinil acheter provigil europe commander modafinil eu acheter modafinil à cats to the effects of modafinil in humans is unknown .

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